If you’ve ever had the misfortune of brushing up against poison ivy, oak, or sumac, you know how relentless the itch and rash can be. It’s not just an inconvenience—it can disrupt your entire week. I’ve tried countless remedies, from calamine lotion to oatmeal baths, but none seemed to truly stop the irritation. That’s when I came across ZANFEL Poison Ivy, Oak & Sumac Wash, a product specifically designed to tackle the root cause of the problem: urushiol, the toxic oil responsible for those itchy rashes.

After hearing mixed reviews and noticing the hefty price tag, I was hesitant but curious. Was this product truly worth the investment? I decided to give it a try and share my honest experience, covering both the highlights and the drawbacks.
Packaging
The first thing I noticed about ZANFEL was its practical tube packaging. It’s a no-frills design, clearly marketed as a functional medicated wash rather than a luxury skincare product. One unique feature I appreciated was the built-in ruler on the packaging, which helps you measure the recommended 1.5-inch dose. This might seem like a small detail, but it ensures you’re not wasting product or using too little to be effective.
The tube arrived sealed, providing tamper-evidence for peace of mind. The label itself is straightforward, listing instructions, ingredients, warnings, and what the product claims to achieve. While it’s not the most eye-catching design, it’s practical and well-organized for its purpose.
Ingredients
ZANFEL primarily uses synthetic ingredients, with the most notable being polyethylene granules. These tiny, gritty particles act as a gentle abrasive, physically lifting urushiol oil from the skin. Other key ingredients include Sodium Lauroyl Sarcosinate, Nonoxynol-9, Disodium EDTA, and Quaternium-15.
While the formula is clinically proven to remove urushiol, some synthetic additives, like Nonoxynol-9 and Quaternium-15, have been flagged for potential skin sensitivity in rare cases. Though the product is advertised as safe for children and pregnant or nursing women, it’s not explicitly labeled as hypoallergenic. If you have particularly sensitive skin, a patch test might be wise.
It’s also worth noting that ZANFEL recently changed its formulation, removing some ingredients present in previous versions. Despite the update, the overall effectiveness remains high, though some long-time users noticed subtle differences.
Size and Texture
The standard size is a 1 oz tube, though larger multi-packs are available for frequent users. The 10-year shelf life is impressive—you can tuck it into your first aid kit without worrying about expiration anytime soon.
Texture-wise, it’s a gritty paste that activates when mixed with water. The polyethylene granules provide enough friction to feel effective without being harsh. It’s slightly gritty, but not unpleasant—like a mild exfoliant. The scent is minimal, more medicinal than fragrant, which I personally prefer for a treatment product.
While the grit is effective, some users might find it slightly abrasive on already inflamed skin. I found it best to rub gently, especially on sensitive areas, to avoid further irritation.
Application
Using ZANFEL is straightforward. After wetting the affected area, you squeeze out 1.5 inches of the paste and rub it into the skin for about three minutes. It quickly lathers into a paste, making it easy to see where you’ve applied it. The product rinses off cleanly, leaving no sticky or greasy residue behind.
One thing to keep in mind: early application is key. The sooner you use ZANFEL after exposure, the better the results. If you’re dealing with a large rash, you might need to work in sections, as the product can dry out if left on too long before rinsing. While it’s marketed as a single-use solution, some users—myself included—found that repeat applications were necessary for stubborn outbreaks.
I also found that pairing ZANFEL with IvyX wipes during outdoor activities was helpful. The wipes are convenient when you don’t have immediate access to water, offering a quick cleanse until you can properly apply the wash.
Effectiveness
Here’s where ZANFEL truly stands out. Within 30 seconds of application, I noticed a significant reduction in itching. It wasn’t just temporary relief—the rash stopped progressing, and the redness began to subside within a few hours. Compared to other remedies like calamine lotion or hydrocortisone cream, ZANFEL worked faster and more effectively.
That said, it’s not a miracle cure for everyone. In severe cases, some users, including myself, found that multiple applications were needed to fully clear the rash. It’s also worth noting that while ZANFEL removes urushiol, it doesn’t prevent exposure. If you’re frequently outdoors, like I am when hiking or gardening, it’s wise to pair ZANFEL with a barrier cream or protective clothing to avoid future outbreaks.
One thing I appreciated was how clean my skin felt afterward—there was no sticky residue, just a feeling of relief and cleanliness.
Brand Reputation
ZANFEL has been around since 1996, positioning itself as a specialist in poison ivy, oak, and sumac relief. The company focuses on effectiveness and safety, emphasizing its clinically proven ability to remove urushiol from the skin.
The product is recommended by pharmacists, physicians, and nurses, which adds credibility. Many outdoor enthusiasts, gardeners, and parents swear by it as a reliable solution for repeated exposures. While some users report varying results, the overall sentiment remains positive, especially for those who act quickly after exposure.
Price and Value
Here’s where things get tricky. At around $29.99 to $44.99 for a 1 oz tube, ZANFEL is significantly more expensive than other poison ivy treatments like calamine lotion or hydrocortisone cream. Considering that each tube provides 3 to 4 uses, frequent users might find the cost prohibitive.
However, the value proposition lies in its effectiveness. For many, the fast relief and prevention of severe reactions justify the price, especially if it helps avoid a trip to the doctor for steroid treatments. If you frequently encounter poison ivy, the long shelf life and proven results might make it a worthwhile investment, despite the upfront cost.
That said, if you’re only occasionally exposed, the high price might outweigh the benefits, especially compared to cheaper alternatives like calamine lotion.
Availability
ZANFEL is widely available both online and in stores. You can find it at major retailers like Walmart, Amazon, and independent pharmacies, as well as specialty outdoor stores like Sherrilltree and Chinook Medical Gear.
It’s also worth noting that knockoff versions are floating around, particularly at some online retailers. These alternatives don’t perform as well, so it’s best to buy from reputable sources to ensure you’re getting the real deal.
- Fast relief from itching within 30 seconds.
- Clinically proven to remove urushiol.
- Safe for children and pregnant women (though not labeled hypoallergenic).
- Long shelf life of 10 years.
- Portable and easy to use.
- Effective even for insect bites and stings, like mosquitoes, chiggers, and wasps.
- High price, especially for frequent users.
- Multiple applications might be needed for severe cases.
- Synthetic ingredients may irritate sensitive skin.
- Doesn’t prevent exposure, only treats after contact.
Overall Rating
Based on my experience, I’d give ZANFEL an 8.5 out of 10. It delivers on its promise of fast, effective relief and stops rash progression, setting it apart from many over-the-counter treatments. However, the high price and occasional need for repeat applications prevent it from earning a perfect score.
If you rarely encounter poison ivy, you might find it too expensive for occasional use. But if you’re frequently exposed during outdoor activities, it’s worth the investment for peace of mind and quick relief.
Important Notes
While ZANFEL is highly effective, it’s not a preventative measure. It removes urushiol after exposure, so you’ll still need to practice outdoor safety to avoid contact in the first place.
Additionally, while most users report positive results, individual experiences vary. If you have sensitive skin, be mindful of the synthetic ingredients and consider a patch test before full application.
Ultimately, ZANFEL is a powerful tool in combating poison ivy, oak, and sumac—but like any product, it’s not without limitations. If you’re prepared for the price and follow the instructions carefully, it’s one of the best options available for fast, effective relief.
From my personal experience, I’d also recommend keeping IvyX wipes handy for quick cleanup when you’re out hiking or camping. They don’t replace ZANFEL but act as a first line of defense until you can properly wash up.